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SB 258719
CAS No. 195199-95-2
SB 258719 ( —— )
产品货号. M26434 CAS No. 195199-95-2
SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥680 | 有现货 |
|
| 10MG | ￥1110 | 有现货 |
|
| 25MG | ￥2244 | 有现货 |
|
| 50MG | ￥3605 | 有现货 |
|
| 100MG | ￥5338 | 有现货 |
|
| 500MG | ￥11178 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SB 258719
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
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产品描述SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.(In Vitro):SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2?of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism.(In Vivo):SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice. Increased Wnt/β-catenin activity was attenuated by SB 258719 in HCC cell lines and patient-derived primary tumour tissues in the presence of 5-HT. SB 258719 also reduced tumour growth in vivo.
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同义词——
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number195199-95-2
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分子量338.5
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分子式C18H30N2O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESC[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shimada Y, et al. Identification of a novel dihydrodaidzein racemase essential for biosynthesis of equol from daidzein in Lactococcus sp. strain 20-92. Appl Environ Microbiol. 2012 Jul;78(14):4902-7.
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